A 16-year-old boy presents with jaundice and splenomegaly. His father had a similar illness during adolescence. MCHC: high. What is the most likely diagnosis?

Options

1. IDA
2. Hereditary spherocytosis
3. Thalassemia major
4. AIHA

Correct Answer

Hereditary spherocytosis

Explanation

Family history + jaundice + splenomegaly + high MCHC = Hereditary spherocytosis. Membrane defect (spectrin, ankyrin) → spherical RBCs → splenic destruction. IDA has low MCHC. Thalassemia major presents early in life. AIHA is acquired, not familial.

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