Which statement is incorrect regarding Samter triad?

Options

1. It is only triggered by aspirin
2. Other NSAIDs with COX-1 blocking ability can also trigger symptoms
3. It is characterized by asthma, nasal polyps, and aspirin sensitivity
4. It involves overproduction of leukotrienes

Correct Answer

It is only triggered by aspirin

Explanation

Samter triad (aspirin-exacerbated respiratory disease) can be triggered by any COX-1 inhibitor, not just aspirin. It is characterized by asthma, nasal polyps, and aspirin/NSAID sensitivity, with overproduction of cysteinyl leukotrienes.

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