Aprepitant, used to prevent late-onset chemotherapy-induced nausea and vomiting, acts through which mechanism?

Options

1. NK-1 antagonist
2. NK-1 agonist
3. NK-3 antagonist
4. NK-2 antagonist

Correct Answer

NK-1 antagonist

Explanation

Aprepitant is a neurokinin-1 (NK-1) receptor antagonist used to prevent chemotherapy-induced nausea and vomiting, particularly delayed emesis. It blocks substance P in the central nervous system.

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