A patient presents with fever, hepatosplenomegaly, abdominal pain, and WBC count > 50,000/mm3. Which genetic abnormality is involved?

Options

1. t(9;22)
2. del(1q)
3. t(15;17)
4. del 3q

Correct Answer

t(9;22)

Explanation

The Philadelphia chromosome t(9;22) creating the BCR-ABL fusion gene is diagnostic of chronic myeloid leukemia (CML). The presentation with marked leukocytosis and hepatosplenomegaly is characteristic.

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