A pregnant woman with a history of bronchial asthma is in the third stage of labour. Which drugs should be avoided in managing postpartum haemorrhage in this mother?

Options

1. Carboprost
2. Oxytocin
3. Dinoprostone
4. Methyl ergometrine

Correct Answer

Carboprost

Explanation

Carboprost is a synthetic prostaglandin F2α analogue used for postpartum hemorrhage. However, it is CONTRAINDICATED in asthmatic patients because: 1) It can cause severe bronchospasm, 2) Prostaglandin F2α causes bronchoconstriction, 3) Can precipitate acute asthma exacerbation. Safe alternatives for PPH in asthmatics include: Oxytocin (first-line), Misoprostol (prostaglandin E1 - causes bronchodilation), and Tranexamic acid. Methylergonovine should be used cautiously as it can cause bronchospasm but is not absolutely contraindicated like carboprost.

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