A 7-year old boy presented with abdominal pain, vomiting, oliguria, and periorbital puffiness following chemotherapy. Investigations reveal hyperuricemia, raised creatinine levels, and hyperkalemia. What is the next best step in the management of this condition?

Options

1. Hydration
2. Probenecid
3. Allopurinol
4. Rasburicase

Correct Answer

Hydration

Explanation

This patient has tumor lysis syndrome (TLS) following chemotherapy. The first and most important step in management is aggressive hydration to maintain urine output and prevent uric acid crystallization in renal tubules.

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