A 10-year-old boy presented with seizures. His past history is significant for an episode of fever with rash at 1 year of age which resolved spontaneously. What is the most helpful investigation to diagnose his condition?

Options

1. IgG measles in CSF
2. MRI mesial temporal lobe sclerosis
3. IgM measles in CSF
4. C1Q4 antibodies in the CSF

Correct Answer

IgG measles in CSF

Explanation

This case describes subacute sclerosing panencephalitis (SSPE), a delayed complication of measles infection. The history of measles at 1 year followed by seizures years later is typical. Diagnosis is confirmed by elevated CSF measles IgG antibodies and high measles antibody titers in serum. IgM indicates acute infection, while IgG indicates past infection and persisting virus.

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