A guy was playing in a garden. Suddenly, he collapsed and was rushed to the hospital. His friend who played with him in the garden informed the doctors that he ate one of the fruits in the garden post which he seemed to have developed these symptoms. He also had irritability, restlessness, dry hot skin, and was unable to pass urine and stools. Identify the poison and its appropriate antidote.

Options

1. Datura, Pralidoxime
2. Datura, Physostigmine
3. Yellow oleander, Digoxin
4. Yellow oleander, Physostigmine

Correct Answer

Datura, Physostigmine

Explanation

The clinical features of dry hot skin, urinary and fecal retention, restlessness, and irritability are characteristic of anticholinergic toxicity from Datura (Dhatura) poisoning. Datura contains tropane alkaloids (atropine, scopolamine). The antidote is physostigmine, a cholinesterase inhibitor that crosses the blood-brain barrier and reverses both central and peripheral anticholinergic effects. The mnemonic for anticholinergic toxicity is "Hot as a hare, blind as a bat, dry as a bone, red as a beet, mad as a hatter".

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