A 30-year-old presented with flaccid bullae on her skin which are easy to rupture. The biopsy revealed a suprabasal split. What is the most likely diagnosis?

Options

1. Pemphigus vulgaris
2. Pemphigus foliaceus
3. Pemphigus vegetans
4. Erythema multiforme

Correct Answer

Pemphigus vulgaris

Explanation

Pemphigus vulgaris is characterized by flaccid, easily ruptured bullae due to loss of intercellular adhesion (acantholysis). Histologically, it shows a suprabasal split with a "row of tombstones" appearance (basal cells attached to basement membrane). Direct immunofluorescence shows IgG deposition in intercellular spaces in a "fishnet" pattern.

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